1973 年 21 巻 12 号 p. 2722-2724
Several aminoethyl and pyrrolidylmethyl thiosulfate and thiophosphate derivatives were synthesized and tested for the radioprotective effect in X-irradiated mice. Sodium hydrogen S-(L-2-pyrrolidylmethyl) phosphorothioate was most protective among ten compounds tested. It was effective to a same extent as cysteamine which is a typical radioprotector. N-Methylpyrrolidyl derivative of the compound was completely inactive. Furthermore, no radioprotection was observed in case of the corresponding thiosulfate.