Abstract
Non-steroidal anti-inflammatory drugs such as phenylbutazone and sulfinpyrazone have been known to bind strongly with plasma proteins and inhibit the binding of a sulfonamide by competing with the drug for the same binding sites on plasma proteins.3, 4)Furthermore, it has been shown that the liberation of a sulfonamide from its binding sites on plasma proteins by the non-steroidal anti-inflammatory drugs affects on the distribution and excretion of the sulfonamide in animals.For example, Anton5) observed that sulfinpyrazone altered the concentration of sulfaethylthiadiazole between plasma and tissues in rats.Also, Arita, et al.6)reported that sulfinpyrazone and oxphenbutazone inhibited the renal tubular secretion of sulfonamides in dogs.However, there is not yet enough evidence to demonstrate the effects of combinations of non-steroidal anti-inflammatory drugs and sulfonamides in view of protein binding.
In the previous paper, 1)the authors demonstrated that the binding of sodium cyclamate and rabbit serum albumin was competitively inhibited by phenylbutazone, consequently the urinary excretion of sodium cyclamate in rabbits was accelerated by simultaneous administration of phenylbutazone.
The purpose of this investigation is to demonstrate the effects of non-steroidal antiinflammatory drugs on the absorption and excretion of sulfadimethoxine in rabbits.
