Thio-analogues of 6-Substituted 1, 3-Dimethyl-7-azalumazine (Fervenulin) and 7-Substituted 1, 3-Dimethyl-6-azalumazine (Isofervenulin)

Abstract

1, 3-Dimethyl-4-thio-7-azalumazine derivatives (5-thiofervenulins) and 1, 3-dimethyl-4-thio-6-azalumazine derivatives (5-thioisofervenulins) were synthesized by the thiation of 1, 3-dimethyl-7-azalumazine derivatives (fervenulins) and 1, 3-dimethyl-6-azalumazine derivatives (isofervenulins). The 1, 3-dimethyl-4-thio-6-azalumazines were converted into theophyllines by treatment with sodium dithionite in formic acid. These thio-azalumazines displayed low antibacterial activities in vitro.