Alkaloids of Corydalis incisa PERS. III. The Structures of Corydamine Hydrochloride and N-Formyl Corydamine

Abstract

Two new alkaloids, corydamine hydrochloride, C₂₀H₁₉O₄N₂Cl, mp235-239° (decomp.) and N-formyl corydamine, C₂₁H₁₈O₄N₂, mp159.5-160.5°, were isolated from Corydalis incisa PERS. (Papaveraceae) and their structures were established to be II and IX, respectively, by spectroscopic analyses and their chemical conversion to coptisine iodide and anhydrodihydroprotopine-B. Corydamine hydrochloride and N-formyl corydamine are noted as the first naturally occurring alkaloids having the 3-phenyl isoquinoline skeleton.