Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on 2-Substituted Thiazolines. L. Reaction with Cyanoacetic Acid
YOZIRO SAKURAIMASATERU KURUMITOSHIYUKI OKUTOMESHIGEO SATOKAZUTAKA YAMAGUCHI
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1973 Volume 21 Issue 7 Pages 1426-1430

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Abstract
2-Substituted thiazokines (IIa-d) were prepared from 2-thiothiazokidone. IIa-d were converted to 2-(ethoxycarbonylcyanomethylene) thiazolidine (III) and its N-acetate and N-methyl derivative. Thiolester analogs of III were obtained by the reaction of IIa-d and cyanoacetic acid in acetic anhydride.
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© The Pharmaceutical Society of Japan
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