Abstract
Effects of surfactants on the thiol-disulfide exchange reaction consisting of thiamine disulfide compounds and thiols were studied as a model system representing changes in drug's stability which would be caused by drug-surfactant interaction. Addition of sodium laurylsulfate, sodium glycocholate or polysorbate 80 to the raction mixture caused, in their own way, a decrease or an increase in the rate of the reaction. The effective factors affecting on the surfactant effects were found to be lipophilic character and structure of the disulfide compounds and also the kind of thiols, e.g. glutathione, cysteine, cysteamine or thiophenol.
