Studies on the Reactions of Heterocyclic Compounds. XI. Methylation of Heteroaromatic N-Oxides

Abstract

N-Oxides of quinoline, isoquinoline, and benzo [f] quinoline were methylated with sodium methylsulfinylmethylide. Methyl group was introduced into the α-position to the N-oxide group in each case, regardless of the charge densities. Reaction mechanism is proposed upon these results.