Abstract
Digitoxigenin oligosaccharides of the 1, 6-β-linked D-glucose series and 1, 4-β-linked D-digitoxose series were obtained by the Konigs-Knorr condensation of digitoxigenin with gentio oligosaccharides and by the partial hydrolysis of digitoxin, followed by chromatographic fractionation of products, respectively. Cardiac activity as well as toxicity increased and decreased with the increasing number of unit monosaccharides for glycosides of the D-glucose and the D-digitoxose series, respectively. There was observed a parallelism between the activity as well as toxicity and the lipophilicity of these glycosides.
