Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on the Ammoxidation of N-Heterocyclic Compounds. IV. Vapor-Phase Ammoxidation of Lutidine Isomers
JUTARO OKADASHUSHI MORITAYOSHIHISA MIWA
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1974 Volume 22 Issue 10 Pages 2402-2406

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Abstract

The kinetics of heterogeneous vapor-phase ammoxidation of lutidine isomers was studied over a Cr2O3-Al2O3 catalyst in a flow system. The reaction was carried out at atmospheric pressure and at a temperature of 360°. 3-Cyano-5-methylpyridine, 4-cyano-3-methylpyridine, 2-cyano-6-methylpyridine, 2-cyano-5-methylpyridine and 2-cyano-3-methylpyridine were produced selectively at low conversion from 3, 5-lutidine, 3, 4-lutidine, 2, 6-lutidine, 2, 5-lutidine and 2, 3-lutidine respectively. 2-Cyano-4-methylpyridine and 4-cyano-2-methylpyridine were produced in same amounts from 2, 4-lutidine. The reaction rate depended on the partial pressure of lutidine and oxygen. Experimental rate data were well interpreted by Langmuir-Hinshelwood mechanism, where the rate determining step was the surface reaction between adsorbed lutidine molecules and adsorbed oxygen molecules.

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