Analogues of Luteinizing Hormone-Releasing Hormone with Modification in Position 8

抄録

Eight analogues of LH-RH, in which arginine residue in position 8 was modified, were synthesized and evaluated for their LH-RH activity. The results suggest that both the size and basicity of the guanidino group, as well as the length of the methylene chain in Arg⁸ residue are important factors for generating full hormonal activity.