Studies on Tetrahydroisoquinolines. VIII. Lead Tetraacetate Oxidation of 1, 2, 3, 4-Tetrahydro-6-hydroxy-7-methoxy-2-methylisoquinoline and Its 1-Substituted Derivatives

Abstract

Lead tetraacetate oxidation of 1, 2, 3, 4-tetrahydro-6-hydroxy-7-methoxy-2-methylisoquinolines (VIIIa-d) in methylene chloride was found to form readily 4-acetoxy-1, 2, 3, 4-tetrahydro-6-hydroxy-7-methoxy-2-methylisoquinolines (XIVa-d) in moderate yield.