Abstract
Ten metabolites of 17α-acetoxy-6-chloro-4, 6-pregnadiene-3, 20-dione were isolated from urine and bile of the rabbit and their chemical structures were determined. The urinary main metabolite was 17α-acetoxy-2ξ, 3ξ-dihydroxy-5ξ-pregnan-20-one. The biliary main metabolite was 17α-acetoxy-6-chloro-2ξ, 3ξ-dihydroxy-4, 6-pregnadien-20-one. The administered compound was metabolized through two courses, one was oxidation at C-2 and another was dechlorination at C-6, in the rabbit. A small amount of the metabolite oxidized at C-21 was identified from urine.
