Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Reaction of Biguanides and Related Compounds. XII. Condensations of Arylbiguanides and Amidinoisoureas with Isatins
古川 潮吉田 孝利林 清五郎
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1974 年 22 巻 12 号 p. 2875-2882

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The reactions of arylbiguanides with isatin and with 1-methylisatin gave 2-oxo-3-arylbiguanidylidene-indoles and 4-amino-6-arylamino-2-(1'-methyl-2'-oxo-3'-indolidene)-1, 2-dihydro-s-triazines, respectively. Analogously, N-amidino-O-alkylisoureas reacted with isatin and 1-methylisatin to afford 2-oxo-3-alkoxyamidinoamidinylidene-indoles and 4-amino-6-alkoxy-2-(1'-methyl-2'-oxo-3'-indolidene)-1, 2-dihydro-s-triazines, respectively. The structures of these compounds were discussed.

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