Experiments on the Synthesis of dl-Camptothecin. II. Synthesis of a D-E Ring Analog of Camptothecin and a Total Synthesis of Ricinine
1974 年 22 巻 4 号 p. 763-770
詳細
1974 年 22 巻 4 号 p. 763-770
A D-E ring analog (XX) of camptothecin (I) was synthesized from 4-methoxy-1-methyl-2 (1H)-pyridone by using Vilsmeier reaction followed by nucleophilic direct introduction of di-tert-butyl malonate onto the pyridone ring, ethylation and hydroxylation.
