抄録
Aminopyrine and its metabolites, 4-aminoantipyrine and N-acetyl-4-aminoantipyrine, were orally administered to human subjects and cumulative amounts of 4-aminoantipyrine and N-acetyl-4-aminoantipyrine excreted in urine were determined. Pharmacokinetic parameters of aminopyrine were estimated by means of least square fit of multi-exponential equations to the urine data.
