Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Passiflora incarnata Dry Extract. I. Isolation of Maltol and Pharmacological Action of Maltol and Ethyl Maltol
NOBUO AOYAGIRYOHEI KIMURATOSHIRO MURATA
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1974 Volume 22 Issue 5 Pages 1008-1013

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Abstract

The compositions of the fractionized samples of Passiflora incarnata dry extract were investigated. Harmine was found in the ether soluble fraction by paper and thinlayer chromatographies. Maltol was isolated from the 2 N HCl soluble fraction. The pharmacological properties of Passiflora incarnata dry extract, the 2 N HCl soluble fraction, maltol and ethyl maltol were investigated. The 2 N HCl soluble fraction decreased the oxygene uptake by rat brain cortex slices at a high concentration. Maltol caused a depression in mice and showed potentiation on hexobarbital induced sleep, anticonvulsant action with such high doses as toxic, and inhibition on the spontaneous motor activity in mice with low doses. Ethyl maltol showed similar actions but more potent anticonvulsant avtivity and less potent inhibitory effects on the spontaneous motor activity.

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© The Pharmaceutical Society of Japan
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