Abstract
N, 2'-O-Dibenzoyladenosine 3'-phosphate was polymerized using dicyclohexylcarbodiimide as the activating reagent to give linear and cyclic oligoadenylic acids. When 5'-O-monomethoxytrityl-N, 2'-O-dibenzoyladenosine 3'-phosphate was added as the chain terminator linear oligoadenylic acids were obtained as major products. Cyclic di- and triadenylic acids were also synthesized by cyclization of the corresponding linear oligonucleotides and were found to be sensitive to RNase M. Their CD spectra were measured in aqueous and methanolic solution.
