Studies on Peptides. XL. Synthesis of the Protected Dodecapeptide corresponding to Positions 1 to 12 of the Basic Trypsin Inhibitor from Bovine Pancreas (Kunitz and Northrop)

Abstract

The protected dodecapeptide, Z-Arg (NO₂)-Pro-Asp (OBzl)-Phe-Cys (Bzl)-Leu-Glu-(OBzl)-Pro-Pro-Tyr-Thr-Gly-OH, corresponding to positions 1 to 12 of the basic trypsin inhibitor from bovine pancreas (Kunitz and Northrop) was synthesized. The synthesis was achieved by condensation of three peptide subunits, Z-Arg (NO₂)-Pro-OH, Z (OMe)-Asp (OBzl)-Phe-Cys (Bzl)-Leu-Glu (OBzl)-Pro-OH and H-Pro-Tyr-Thr-Gly-OH with pentachlorophenyl trichloroacetate.