Metabolism of Triphenylmethane Colors. I. Absorption, Excretion, and Distribution of Guinea Green B (FD and C Green No. 1) in Rats
1974 年 22 巻 9 号 p. 2042-2047
詳細
1974 年 22 巻 9 号 p. 2042-2047
Absorption, excretion, and distribution of Guinea Green B were investigated in rats. This color was hardly absorbed when given orally ; only 2.28% of the dose of the color was recovered in the bile after 24hr. The cumulative recovery of biliary excretion amounted to 86.5% at 4hr and 96.5% at 24hr after intravenous injection. The color was not metabolized except the formation of the leuco form in the large intestine. In the case of intravenous injection, the color disappeared rapidly from various tissues except in the liver and kidney.
