Chemical Conversion of Stepinonine to Bisbenzylisoquinoline Alkaloids

Abstract

Stepinonine (1) was chemically converted to O-methylrepandine (2) and O-methyloxyacanthine (3) via N, O-dimethyltetrahydrostepinonine (17) which was subjected to oxidation with Jones' reagent, followed by reduction with Zn-AcOH and NaBH₄.