Abstract
2-(2-Hydroxy-5-n-hexylphenyl)-8-quinolinol-4-carboxylic acid (HQ II), as an analogue of 2-(2-hydroxyphenyliminomethyl)-4-n-hexylphenol (HP) which exhibits anticancer activity, was prepared by the method of Doebner synthesis. HQ II, having the ability to form metal complexes with several metallic ions as well as HP, inhibited prominently the growth of Ehrlich ascites carcinoma and ascites hepatoma AH 13 in animals. However, it was not effective against L1210, solid tumors of both Sarcoma 180 and Ehrlich carcinoma and Yoshida sarcoma. From the results of preliminary examinations which were carried out to obtain some information concerning the mode of action of HQ II on cancer cells, it was suggested that the cell membrane injury and the inhibition of nucleic acid synthesis might be contributable to the HQ II effect on the susceptive cancer cells.
