Abstract
In the chromic acid oxidation of 2-aminomethyl-5-chloro-1-methyl-3-phenylindole (1) to 7-chloro-1, 3-dihydro-1-methyl-5-phenyl-2H-1, 4-benzodiazepin-2-one (2), 1 reacts rapidly with chromic acid to form an oxidation intermediate A, which on acetylation with acetic anhydride gives 2-acetamido-2'-benzoyl-4'-chloro-N-methylacetanilide (3). The rate for formation of 2 from A has been determined by following the change of the quantities of 2 and 3 obtained by periodical sampling followed by quenching with acetic anhydride. The rate is first order with respect to the concentration of A.
