抄録
Analogously to the Strecker degradation method, α-amino acids were converted to carbonyl derivatives by treatment with N-sulfinylaniline below 100° in dimethylsulfoxide (or benzene). The sodium salts prefer to the free acids as substrates (35-75% yield). In contrast with other α-amino acids, glycine was further oxidized to formic acid derivative. Also, α-amino acid ethyl esters were submitted to the same treatment and usually converted to keto acid esters as expected. However, the reaction of ethyl glycinate proceeded unordinarily to afford diethyl 1, 2, 5-thiadiazole-3, 4-dicarboxylate. The degradation reaction pathway of α-amino acids was discussed with some evidences and speculations.
