When N-oxides of 2, 5-dimethylpyrazine and their 3, 6-disubstituted (chlorine or alkoxy) derivatives were reacted with phosphorus oxychloride, various compounds substituted by chlorine on the nucleus and/or on the methyl group (s) were produced in low yields. Accordingly, a few kinds of other acid chlorides were examined to elevate the yields, but no one could improve the results. Chlorinated compounds thus obtained were converted to their corresponding alkoxy derivatives (methoxy, ethoxy or benzyloxy).
