Abstract
The titled compounds (1, 2) have been prepared from estrone by the new synthetic routes. Introduction of a hydroxyl group into the 15α-position was readily attained by hydroboration of the 14, 15-or 15, 16-double bond with diborane and subsequent oxidation of the organoborane with alkaline hydrogen peroxide. In the preparation of 1 the dimethyl-tert-butylsilyl function was conveniently employed for the purpose of protecting the 3, 17β-hydroxyl groups.
