Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Rate of Release of Medicaments from Ointment Bases Containing Drugs in Suspension
TAMOTSU KOIZUMIMICHIHIRO UEDAMASAWO KAKEMIHARUKO KAMEDA
Author information
JOURNAL FREE ACCESS

1975 Volume 23 Issue 12 Pages 3288-3292

Details
Abstract
Higuchi's equation that expresses the rate of release of medicaments from ointments containing drugs in suspension has long been used for its surprisingly simple form and convenience. If initial drug concentration is close to the solubility of the drug in the ointment base, however, accuracy of the equation is not always high. In order to improve the accuracy, explicit solution of Fick's laws with the appropriate boundary conditions was attempted.
Content from these authors
© The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top