Author's Organization：Faculty of Pharmaceutical Sciences, University of Toyama Gofuku, Toyama Faculty of Pharmaceutical Sciences, University of Toyama Gofuku, Toyama Faculty of Pharmaceutical Sciences, University of Toyama Gofuku, Toyama Faculty of Pharmaceutical Sciences, University of Toyama Gofuku, Toyama
A practical synthetic method of 21-dimethoxypregn-14-en-20-ones which are key intermediates in bufadienolide syntheses is described. It involves 21-thiomethylation of pregn-14-en-20-ones followed by oxidation with N-chlorosuccinimide in methanol.
