Studies on Optical Rotatory Dispersion and Circular Dichroism. II. Circular Dichroism of α-Hydroxy-and α-Amino-α-phenyl Ketones

Abstract

Studies on circular dichroism of some open chain α-hydroxy-, α-amino-, and α-acyl-amido-α-phenyl ketones known of their absolute configurations demonstrated a good agreement between the rule of β, γ-unsaturated ketones and the experimental results in nonpolar solvents with a support of conformational analyses using their infra red spectra. In the course of the studies, the absolute configuration of (+)-α-ethylphenylglycine (2-amino-2-phenylbutyric acid) ((+)-V) was concluded to have S-configuration.