Author's Organization：Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology, Ohokayama, Meguro-ku, Tokyo Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology, Ohokayama, Meguro-ku, Tokyo Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology, Ohokayama, Meguro-ku, Tokyo Teijin Institute for Biomedical Research, Hino-shi, Tokyo Teijin Institute for Biomedical Research, Hino-shi, Tokyo
24ξ, 25-Dihydroxycholesterol was converted, through 1, 4, 6-trien-3-one and its 1α, 2α-epoxide, into 1α, 24ξ, 25-trihydroxycholesterol. After resolution of C-24 epimers and determining their configurations, both isomers were led to [24R]- and [24S]-1α, 24, 25-trihydroxyvitamin D3 by bromination, dehydrobromination and ultraviolet-irradiation.
