Abstract
After the administration of antipyretics, the pharmacological response intensity versus time course was expressed quantitatively using a pharmacokinetic method. Acetaminophen and 4-aminoantipyrine were used as the antipyretics. After the administration of these drugs, plasma level, brain level and urinary excretion of the drug were determined as the drug disposition data. Metabolic rate, vaporization rate, rectal temperature and skin temperature were also determined as the pharmacological effects. From the observed data, an electrical analog was constructed to simulate the effects of antipyretics including physiological thermoregulation. The results indicate that the time course of pharmacological effects are reasonably simulated by a single mathematical model.
