Mass Fragmentographic Determination of 1-Piperidino-2, 4'-dimethylpropiophenone (Mydocalm) by Use of 1 : 1 Mixture Technique

Abstract

Artificially created cluster technique has been used for the quantitative determination of serum levels of 1-piperidino-2, 4'-dimethylpropiophenone (Mydocalm). A mixture of unlabeled drug and stable isotope labeled drug (Mydocalm-¹⁵N) was orally administered for identification of Mydocalm. Decadeuterium labeled Mydocalm (Mydocalm-d₁₀) was prepared and used as an internal standard and carrier for determination. A 100 mg dose of Mydocalm has been given orally to 3 subjects.