Abstract
Some amidinothiocholine derivatives have been prepared and tested for the ganglion blocking activity, as compared with that of hexamethonium. Among them, most potent ganglionic blocking compound was S-(2-trimethylaminoethyl)-1'-ethylisothiuronium which was more potent than hexamethonium on the cat superior cervical ganglion, the guineapig hypogastric nerve-vas deferens preparation and the cat and rat blood pressure. Other compounds, also, had the ganglionic blocking action, but were not so potent as hexamethonium.
