Abstract
Cyclization reactions of 8-(β-haloethylthio) adenine, 8-(β-haloethylamino) adenines and 8-(γ-halopropylamino) adenine occurred at both of N7 and N9 of purine ring and pairs of cyclized compounds, 4-aminodihydrothiazolo [2, 3-f]-and 4-aminodihydrothiazolo [3, 2-e] purine, 4-aminodihydroimidazo [2, 1-f]-and 4-aminodihydroimidazo [1, 2-e] purines, and 4-aminotetrahydropyrimido [2, 1-f]-and 4-aminotetrahydropyrimido [1, 2-e] purine were obtained. Structures of 4-aminodihydrothiazolopurines were determined by desulfurization with Rany Ni and those of 4-aminodihydroimidazopurines and 4-aminotetrahydropyrimidopurines were determined by comparison of spectral data with those of N-cyclonucleosides.
