Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
A Simple Method for the Measurement of the Cardiac Afferent Activities as affected by Drugs, using the Perfused Heart of the Bullfrog
福田 秀男石河 醇一
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ジャーナル フリー

1975 年 23 巻 9 号 p. 2145-2147

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抄録
Afferent activity from baroreceptors in the isolated heart of the bullfrog was recorded. Two types of volley were observed during the period of the cardiac cycle : a lasting volley of discharges accompanying the QRS complexes in electrocardiogram and a short volley of discharges following immediately after the P wave. Epinephrine, veratridine and ouabain caused an increase in the rate of afferent discharges from baroreceptors in the heart, whereas acetylcholine and ajmaline caused a reduction in the rate. Thus this method allowed a simple measurement of the effect of drugs on the cardiac afferent activities.
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© The Pharmaceutical Society of Japan
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