Breynins, New Sulfur-containing Glycosides with Hypocholesterolemic Activity

HIDEO KOSHIYAMA; MASAMI HATORI; HIROAKI OHKUMA; FUMIHIDE SAKAI; HIDEYO IMANISHI; MASARU OHBAYASHI; HIROSHI KAWAGUCHI

doi:10.1248/cpb.24.169

HIDEO KOSHIYAMA, MASAMI HATORI, HIROAKI OHKUMA, FUMIHIDE SAKAI, HIDEYO IMANISHI, MASARU OHBAYASHI, HIROSHI KAWAGUCHI

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JOURNAL FREE ACCESS

1976 Volume 24 Issue 1 Pages 169-172

DOI https://doi.org/10.1248/cpb.24.169

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Abstract

Breynins are new sulfur-containing glycosides extracted from Breynia officinalis HEMSL (Family Euphorbiaceae). Two major components, breynins A (C₄₀H₅₆O₂₃S) and B (C₄₀H₅₆O₂₄S), were isolated and characterized. Breynins A and B showed significant hypocholesterolemic activity in rats at a daily dose of 0.005 mg/kg and 0.025 mg/kg, respectively.

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