Synthesis of Compounds related to Antitumor Agents. IV. On the Reaction of Aromatic Carboxylates with 2, 4-Diamino-5-hydroxy-6-methylpyrimidine

抄録

Attempts to prepare oxazolo [4, 5-d] pyrimidines by the reaction of 2, 4-diamino-5-hydroxy-6-methylpyrimidine (I) with aromatic carboxylates. The products were carbinolamines which were converted to oxazolo [4, 5-d] pyrimidines. Also, the application of the Salol reaction of I gave 5-amino-2-(2, 4-diamino-6-methylpyrimidin-5-yl)oxy-2-o-hydroxyphenyl-7-methyl-3H-oxazolo [4, 5-d] pyrimidine (XI) which was an unusual product in this reaction.