Abstract
The production of the antibiotic, racemomycin-A, was found to be inhibited in the presence of glucose in the medium, although glucose was the best carbon source for Streptomyces lavendulae ISP 5069. The repression by 1% glucose was gradually restorde by the addition of Pharmamedia or amino acid mixture. A severe repression by glucose was also observed at the rapid phase of antibiotic production. On the repression, racemomycin-A produced was incorporated into the mycelium. Xylose and mannitol were weakly repressed on racemomycin-A formation, and maltose caused a mild stimulation of the formation. The production of streptothricin antibiotics in all organisms tested was inhibited by glucose.
