A series of 2-(N-substituted amino) methyl-2, 3-dihydrobenzofurans were synthesized in order to examine the effect of the N-substituent on their analgesic activity. Some of these compounds demonstrated a good analgesic activity when tested by the acetic acid writhing method in mice. 2-(3-Phenylpropylamino) methyl-7-methoxy-2, 3-dihydrobenzofuran (4i) showed the most potent activity in this series.
