Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Stimulation of Serum Protein Synthesis in Ginsenoside Treated Rat
柴田 泰生野崎 とも子東 悳彦真田 修一庄司 順三
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1976 年 24 巻 11 号 p. 2818-2824

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Ginsenosides Rb1 and Rc purified from the ethanol extract of a root of Panax ginseng were administered into rats at the dose of 5 mg/100 g of body weight. After 3 hours of the administration, biosynthesis of rat serum protein was stimulated at 2 times and more than the control, in 1 hour 14C-amino acid incorporation experiment. From the analyses of serum proteins by salting-out, electrophoresis and NaBr flotation, apoproteins of chylomicrons and very low density lipoprotein showed mostly stimulated synthesis by the treatment with ginsenosides. This coincided with the stimulation of cholesterol synthesis reported previously, and a possible relationship between the synthesis of lipids and that of apo-lipo-proteins was discussed.
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© The Pharmaceutical Society of Japan
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