Abstract
Calcium D (+)-pantothenate crystallized from various solvents was proved to have three polymorphs (α-, β-, and γ-form), an amorphous form and a solvate which contained 4 molecules of methanol and 1 molecule of water of crystallization. It was also found that the solvate was changed to the amorphous form by drying, to α-form on standing in a closed container at temperatures above 30° and to the monohydrate on standing in atmosphere. The data of X-ray powder diffraction, infrared spectroscopy and dissolution behavior are presented for the identification of these various forms.
