Abstract
Some effects of dosage form on absorption of vitamin A into thoracic duct were studied in rats fed vitamin A. Forty-five % of administered vitamin A was recovered in lymph when vitamin A was given in micellar solution form, while 29% of administered vitamin A was recovered when vitamin A was given in triolein solution form. The time courses of appearance of vitamin A in lymph of these two kinds of preparation were very different one another. Vitamin A appearance in lymph showed a sharp peak between 1 and 2 hr after the administration in micellar solution form and indicated the almost complete absorption of vitamin A, while it showed a broad band over 4 hr after the administration in oily solution form. The time courses of vitamin A in serum did not exactly reflect those in lymph.
