Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Methanesulfonic Acid Derivative of N-Alkyl Aniline : Basicity of Aniline and Reactivity
YUKIHISA KURONOKEN IKEDAFUMIKO YAMAMURATOSHIHISA YOTSUYANAGI
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1976 Volume 24 Issue 2 Pages 349-352

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Abstract

Effect of N-alkyl substituents on the formation and hydrolysis rates of N-substituted aniline methanesulfonic acid derivatives were investigated in connection with substituted aniline derivatives. Their rates were satisfactorily correlated to the basicity of aniline derivatives which was corrected by hydration effect, that is Folkers, et al.'s H value.

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© The Pharmaceutical Society of Japan
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