Abstract
Triacetyl-8-oxyinosine (Ib) was treated with phosphoryl chloride in diethylaniline or thionyl chloride in dimethyl formamide (DMF) to give only 6-chloro-8-oxy compound (IV). Treating (Ib) with phosphoryl chloride in tri-n-butylamine gave 6, 8-dichloro compound (VII). Compound (VII) was converted to bis (methylmercapto) compound (VIII) and treated successively with dimethylamine and Raney nickel to give N6-dimethyladenosine. Thus, a procedure for eliminating 8-oxy function of purine nucleosides has been substantiated.
