Amino Acids and Peptides. XX. Reduction of α-Substituted α-Diazo Esters. Convenient Synthesis of α-Hydrazinocarboxylic Acids and Their Derivatives from α-Amino Acids

Abstract

α-Substituted α-diazoesters (I), readily prepared from α-amino acid esters, were reduced with various reductants to give corresponding α-hydrazinocarboxylic acids (II) and their derivatives. Several investigations were also undertaken in order to synthesize α, α-disubstituted α-hydrazinocarboxylic acid derivatives (VII) from I.