Benzodiazepine. XIII. Syntheses of 1, 4-Benzodiazepine Derivatives
1976 年 24 巻 5 号 p. 1076-1082
詳細
1976 年 24 巻 5 号 p. 1076-1082
Oxidation of 3-methyl-or benzyl-substituted or unsubstituted 2-aminomethylindole was described. 1, 4-Benzodiazepin-2-one derivatives (VIIa-c) were synthesized by oxidative ring enlargement of corresponding 2-aminomethylindole derivatives (VIa-c). Also, oxidation of VIa and VIc with O3 gave 1, 4-benzodiazepin-2, 5-dione derivatives VIIIa and VIIIc, respectively, oxidation of VIa with CrO3 gave isatin derivative IX and oxidation of VIc with H2O2 afforded 2-oxindole derivative X as unexpected product.
