1976 Volume 24 Issue 6 Pages 1376-1383
The metabolism and urinary excretion of aminopyrine in man were examined after an oral administration of drug solution. The metabolites were identified and measured quantitatively by gas chromatography and gas chromatography-mass spectrometry. For the microanalysis of metabolite, mass fragmentography was applied. It was clarified that a new metabolite, 4-formylaminoantipyrine, was detected in all cases and it must be noticed as an important metabolite. It was also meaningful that the individual difference among subjects in their urinary excretion behavior of aminopyrine was remarkable beyond our expectations.