Studies on Prostaglandins. III. Synthesis of Bicyclo [4. 3. 0] nonane Derivatives

Abstract

3-(4-Carboxybutylidene)-7α, 9α-dihydroxy-4-hexyl-1βH, 6αH-bicyclo [4.3.0] nonane (III) and 3-(4-carboxybutylidene)-7α, 9α-dihydroxy-4-(1-hydroxyhexyl)-1βH, 6αH-bicyclo [4.3.0]-nonane (IV) were synthesized as prostaglandin-derivatives which were related to steroids. Preliminary in vitro studies on isolated guinea pig ileum have shown that IV possessed weakly PG-like contraction activity (1/300 of PGF_2α) and III did not possess the PG-like activity.