Pharmacological Study on the Aortic Arch Baroreceptors in the Rabbit

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The afferent impulses from the aortic arch baroreceptor in the left aortic nerve of rabbits were recorded in situ and in the perfused preparation. Epinephrine, acetylcholine, lyoniol-B and ouabain excited the baroreceptor in both preparations. Propranolol and N-propyl ajmaline decreased the rate of afferent impulses in the in situ preparation, but had no influence in the perfused preparation. Possible mechanisms of these drugs affecting the impulse activity in the aortic nerve are discussed.