It was demonstrated that acetanilide hydroxylation in man is saturated by as small as 0.5 g dose. Subjects ingested low dose (100 mg) and high dose (500 mg) of acetaminophen and acetanilide. Total acetaminophen (free and conjugated) excreted in urine was determined. Ratio of amount excreted (RAE) between two dose levels was calculated. Saturation of pharmacokinetic process was verified by the value of regression coefficient of RAE to t.
