Abstract
Drug absorption across the skin has been interpreted as the diffusional mass transfer of the drug starting from the vehicle, travelling through the skin tissue, and terminating at the blood stream. There may be some non-diffusional resistance against the drug migration at the vehicle-skin interface and the skin-blood interface. Simulation calculation using an electronic computer can be applied to this simple model of the thickness of the administrated vehicle, that of the skin, the diffusion coefficient in the vehicle, that in the skin, the partition coefficient between these two phases, and the non-diffusional resistance at the vehicle-skin and the skin-blood interface. The present paper describes the method of simulation which has been applied to the experimental results detailed in the succeeding paper.
